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Research Project Description and Objectives from Jennifer Speth, PhD, MCRF 2017 Fellow
Project Name: Defining the Role of Alveolar Macrophage Secreted SOC3 in Lung Cancer
Lung cancer is the leading cancer killer in both men and women and has a five-year survival rate of only 18%. The majority of lung cancers arise from epithelial cells which are the structural cells that line the inside of the lung. Homeostatis is the balanced state where everything functions normally; lung cancer is thought to develop as a result of altered homeostasis and unrestrained inflammation in the lung environment. In the normal lung, homeostasis is maintained by communication between epithelial cells and the resident immune cell of the lung, the alveolar macrophage. The alveolar macrophage functions as the patroller or security guard in the lung. The alveolar macrophage communicates with epithelial cells to send signals to other cells when help is needed to clear infection, so it is very important that they communicate effectively to each other to manage the immune response effectively.
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